Responses of distal nephron Na+ transporters to acute volume depletion and hyperkalemia
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منابع مشابه
Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition.
During angiotensin II (ANG II)-dependent hypertension, ANG II stimulates, while hypertension inhibits, Na(+) transporter activity to balance Na(+) output to input. This study tests the hypothesis that ANG II infusion activates Na(+) transporters in the distal nephron while inhibiting transporters along the proximal nephron. Male Sprague-Dawley rats were infused with ANG II (400 ng·kg(-1)·min(-1...
متن کاملTubuloglomerular and connecting tubuloglomerular feedback during inhibition of various Na transporters in the nephron.
Afferent (Af-Art) and efferent arterioles resistance regulate glomerular capillary pressure. The nephron regulates Af-Art resistance via: 1) vasoconstrictor tubuloglomerular feedback (TGF), initiated in the macula densa via Na-K-2Cl cotransporters (NKCC2) and 2) vasodilator connecting tubuloglomerular feedback (CTGF), initiated in connecting tubules via epithelial Na channels (ENaC). Furosemide...
متن کاملUpregulation of H+-ATPase in the distal nephron during potassium depletion: structural and functional evidence.
In the present study, we have investigated the effects of dietary potassium depletion on the activity and distribution of the H+-ATPase in the distal nephron of the Sprague-Dawley rat. H+-ATPase activity was assessed from the change in transepithelial potential difference ( V te) in response to bafilomycin A1 during perfusion of the late distal tubule in vivo, with solutions containing inhibito...
متن کاملShort-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron
In Sprague Dawley rats, 2-week angiotensin II (AngII) infusion increases Na(+) transporter abundance and activation from cortical thick ascending loop of Henle (TALH) to medullary collecting duct (CD) and raises blood pressure associated with a pressure natriuresis, accompanied by depressed Na(+) transporter abundance and activation from proximal tubule (PT) through medullary TALH. This study t...
متن کاملDistribution of transporters along the mouse distal nephron: something old, something borrowed, something new.
THIS ISSUE OF the American Journal of Physiology: Renal Physiology contains two important papers describing the immunolocalization of transporters in the distal tubules of the mouse (3, 6). There are many reasons for the special interest in the organization of this region of the mouse nephron. The distal convoluted tubule (DCT) plays a critical role in regulating renal Na, Ca, and Mg excretion ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2017
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00668.2016